Erythema Multiforme
I. Definition:
Erythema multiforme is an allergic reaction with
many different causes. It can affect people of all ages and is often more severe in
children and young adults. Erythema multiforme often starts as a red rash on the palms,
soles, and back of the hands. It can spread to the trunk, face, and mouth in severe cases.
Some people only have erythema multiforme in the mouth. As the skin lesions age they often
look like small targets with purple to dusky centers surrounded by red rings. The
condition can be associated with fever, muscle aches, and not feeling well.



II. Causes:
- There are many causes of erythema multiforme.
These include allergic reactions to viral, bacterial, and fungal infections; sensitivity
to food or drugs; immunizations; or sometimes it occurs in association with other
disorders.
- The most common causes of erythema multiforme are Mycoplasma
pneumonia, cold sores, herpes of the genitals, and as a reaction to medication (sulfa
drugs).
- Erythema multiforme is not contagious.
- Some people have recurrent episodes of erythema
multiforme, usually due to cold sores or herpes infection.
III. Treatment:
- A mild cortisone applied directly to the irritated
skin areas, colloidal baths, and wet compresses may be helpful to facilitate the clearing
of the lesions.
- The most important treatment is to stop any
medication that might be causing your rash. Only stop medicines you have been taking if
your doctor tells you to.
IV. Prognosis:
- The development and clearing of the skin lesions
occur in approximately one week, but the rash may continue to appear in certain areas of
the body, for as long as two or three weeks.
- Sometimes erythema multiforme makes people very
sick and they have to be monitored in the hospital. If you develop mouth lesions call your
doctor immediately.
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